Sometimes a graphic helps. Here is how God designed the universe. All things He made are defined by their relationship to Him. We function rightly when our relationship to all other things is properly aligned by seeing those things as they related to Him, or, to put it another way, we can only relate to the created universe as we relate to it through the One who made it and gives it meaning.
But here is man in his rebellion, and hence man in almost all man-derived philosophical systems. By making God the object of our inquiry, we place ourselves in the center. This requires us to define our relationship to all else, including God. We are now directly responsible to define the universe—something we were never designed to do. Epistemological anarchy is the inevitable result. We are insufficient for the task, and the result is disintegration and chaos.